Cloned (Comment) | Organism |
---|---|
DGAT1, functional expression of the FLAG-tagged enzyme in membranes of Spodoptera frugiperda Sf9 cells and in COS-7 cells, expression analysis | Mus musculus |
DGAT2, functional expression of the FLAG-tagged enzyme in Spodoptera frugiperda Sf9 cells, expression analysis | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | DGAT2 overexpression also increases wax monoester synthase activity in intact cells | Mus musculus |
additional information | the wax diester synthase activity of DGAT1 helps to explain the deficiency of type II wax diesters in the fur lipids of Dgat-/- mice, DGAT1 deficiency also perturbs retinol metabolism in the livers of Dgat-/- mice, hepatic levels of unesterified retinol are increased in Dgat-/- mice challenged with high-retinol diets | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,2-dioleoylglycerol + palmitoyl-CoA | Mus musculus | - |
1,2-dioleoyl-3-palmitoylglycerol + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9DCV3 | DGAT2 | - |
Mus musculus | Q9Z2A7 | DGAT1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
additional information | expression analysis | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Mus musculus |
additional information | - |
recombinant enzyme in Sf9 cell membrane and in COS-7 cell membranes, multifunctional enzyme | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,2-dioleoylglycerol + palmitoyl-CoA | - |
Mus musculus | 1,2-dioleoyl-3-palmitoylglycerol + CoA | - |
? | |
additional information | DGAT1 is also catalyzing the reactions of the monoacylglycerol transferase, EC 2.3.1.22, of the wax synthase, EC 2.3.1.75, and of the acyl-CoA:retinol acyltransferase, EC 2.3.1.76, overview | Mus musculus | ? | - |
? | |
additional information | DGAT1 is catalyzing the reactions of the monoacylglycerol transferase, EC 2.3.1.22, of the diacylglycerol transferase, EC 2.3.1.20, of the wax synthase, EC 2.3.1.75, and of the acyl-CoA:retinol acyltransferase, EC 2.3.1.76, overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DGAT | - |
Mus musculus |